I had a problem recently with McAfee and TSM not playing nice together. Jared Annes (co-worker) figured out the problem and this is his finding. What happened was that changes to the default scanning and file protection procedures were made to McAfee to “lock down” the servers from viruses. Unfortunately the SA’s inadvertently caused TSM to fail every system state and system services backup. The culprit was one file, TFTP.EXE in the System32 folder due to McAfee locking the file from being read. What I didn’t expect was that a failure of one file would cause TSM to fail on the whole system state and system services backup. I forgot the system state and services are looked at as one object instead of multiple files. The fix was to disable McAfee, then delete TFTP.EXE from the hidden dllcache folder, also from the System32 folder, and then re-enable McAfee. Since then I have had no more troubles with the system state and services backups.
NOTE: If you don’t delete the file from the dllcache folder Windows will copy it back over to the System32 folder recreating the problem you were trying to fix.